Fig. 1. Experimental design. Schematic diagram of the experimental design to evaluate post-stroke neurological recovery. Rats were subjected to 2h ischemia followed by 7 days reperfusion with neurological evaluations on reperfusion days 1, 3, 5, and 7, and before ischemia and TTC staining at one-day reperfusion. Appropriate cohorts were administered with either vehicle or exosomes intravenously via tail vein immediately after reperfusion. Rats were trained for beam-walk and Rotarod tests at least for 3 days prior to the induction of ischemia.